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butabarbital will reduce the level or impact of fedratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Influence of coadministering a powerful CYP3A4 inducer with fedratinib has not been studied.butabarbital will minimize the extent or influence of carvedilol by influencing hepatic enzyme CYP2C9/10 metab